Abirapro 500mg tablet is prescribed for:

• Metastatic prostate cancer (with prednisone)
• Hormone-refractory prostate cancer

Mechanism of Action

• Contains abiraterone acetate (CYP17 inhibitor)
• Blocks androgen production in testes/adrenals
• Slows prostate cancer progression

Dosage & Administration

• Standard dose: 500mg once daily
• Must be taken on empty stomach (1 hour before/2 hours after food)
• Always combined with prednisone
• Swallow tablet whole with water

Manufacturer

• Produced by Glenmark Pharmaceuticals Ltd

Important Safety Information

Contraindications:

• Severe liver impairment
• Pregnancy/breastfeeding
• Hypersensitivity to abiraterone

Precautions:

• Regular monitoring required for:
• Liver/kidney function
• Blood pressure
• Potassium levels
• Blood cell counts
• Avoid alcohol and smoking

Potential Side Effects

Common:

• Fatigue
• Joint pain/swelling
• Hot flashes
• High blood pressure
• Digestive issues

Serious (seek medical help):

• Severe liver toxicity
• Heart rhythm abnormalities
• Adrenal insufficiency
• Bone fractures

Drug Interactions

• Avoid with:
• Strong CYP3A4 inducers (rifampicin, carbamazepine)
• CYP2D6 substrates (tamoxifen)
• Medications affecting heart rhythm

Special Populations

• Not for use in women/children
• Elderly patients require close monitoring

Missed Dose/Overdose

• Missed dose: Skip if next dose is due soon
• Overdose: Seek emergency care

Storage Instructions

• Store at room temperature (15-30°C)
• Protect from moisture and light
• Keep in original packaging

Note: Patients must use effective contraception during treatment. Regular blood tests are essential to monitor treatment response and side effects. Report any new symptoms to your oncologist immediately.